An isogeometric analysis framework for ventricular cardiac mechanics

Abstract The finite element method (FEM) is commonly used in computational cardiac simulations. For this method, a mesh constructed to represent the geometry and, subsequently, approximate solution. To accurately capture curved geometrical features many elements may be required, possibly leading unnecessarily large computation costs. Without loss of accuracy, reduction cost can achieved by integrating representation and solution approximation into single framework using isogeometric analysis (IGA) paradigm. In study, we propose an IGA suitable for echocardiogram data mechanics, where show advantageous properties smooth splines through development multi-patch anatomical model. A nonlinear model discretized following paradigm, meaning that spline parametrization directly discretization physical fields. benchmarked with state-of-the-art biomechanics based on traditional FEM. benchmark, hemodynamic response predicted high-fidelity FEM captured only 320 4700 degrees freedom. study concluded brief anatomy-variation analysis, which illustrates geometric flexibility framework. as first step toward efficient workflow improved understanding of, clinical decision support for, treatment diseases like heart rhythm disorders.